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Yoshio Hirabayashi Selected Research

Type I Schindler Disease

1/2005Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease): different gene mutations cause peculiar structural changes in alpha-NAGAs resulting in different substrate specificities and clinical phenotypes.
5/2002Immunoelectron microscopic analysis of lysosomal deposits in alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum.

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Yoshio Hirabayashi Research Topics

Disease

6Parkinson Disease (Parkinson's Disease)
10/2021 - 12/2015
6Gaucher Disease (Gaucher's Disease)
10/2021 - 11/2013
5Obesity
09/2021 - 01/2010
5Insulin Resistance
09/2021 - 12/2016
3Neoplasms (Cancer)
06/2020 - 07/2008
3Alzheimer Disease (Alzheimer's Disease)
05/2013 - 08/2006
3Melanoma (Melanoma, Malignant)
04/2013 - 01/2004
2Fabry Disease (Fabry's Disease)
01/2021 - 05/2002
2Schizophrenia (Dementia Praecox)
04/2020 - 12/2010
2Inflammation (Inflammations)
01/2018 - 12/2016
2Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
03/2016 - 06/2005
2Temporal Lobe Epilepsy
12/2014 - 07/2009
2Epilepsy (Aura)
12/2014 - 07/2009
2AIDS-Related Complex (ARC)
09/2014 - 12/2010
2Virus Diseases (Viral Diseases)
01/2013 - 02/2006
2Leukemia
05/2011 - 06/2010
2Experimental Melanoma
05/2011 - 02/2006
2Type I Schindler Disease
01/2005 - 05/2002
1Body Weight (Weight, Body)
09/2021
1Starvation
09/2021
1Retinal Diseases
01/2021
1Phosphoglycerate Dehydrogenase Deficiency
01/2021
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2021
1Overnutrition
01/2021
1Bipolar Disorder (Manic Depressive Psychosis)
04/2020
1Major Depressive Disorder (Major Depressive Disorders)
04/2020
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
07/2019
1Mitochondrial Diseases (Mitochondrial Disease)
10/2018
1Dementia (Dementias)
12/2015
1Seizures (Absence Seizure)
12/2014
1Oligodendroglioma
10/2014
1Neuroblastoma
07/2012
1Ischemia
11/2009
1Cardiovascular Diseases (Cardiovascular Disease)
11/2009
1Osteosarcoma (Osteogenic Sarcoma)
07/2009
1Microcephaly
08/2008
1Pheochromocytoma
10/2007
1Infections
02/2006
1Human Influenza (Influenza)
02/2006

Drug/Important Bio-Agent (IBA)

6CeramidesIBA
01/2021 - 07/2008
6SphingolipidsIBA
01/2021 - 09/2016
4Proteins (Proteins, Gene)FDA Link
09/2021 - 04/2013
3Glucosylceramidase (Glucocerebrosidase)IBA
10/2021 - 12/2015
3Glucose (Dextrose)FDA LinkGeneric
09/2021 - 01/2010
3Serine (L-Serine)FDA Link
01/2021 - 08/2008
3Glucosylceramides (Glucocerebrosides)IBA
01/2021 - 07/2012
3ceramide glucosyltransferaseIBA
11/2020 - 05/2011
3GangliosidesIBA
05/2013 - 07/2005
2SynucleinsIBA
10/2021 - 12/2015
2Insulin (Novolin)FDA Link
09/2021 - 10/2018
2LipidsIBA
01/2021 - 10/2018
2Tyrosine (L-Tyrosine)FDA Link
06/2020 - 01/2018
2alpha-SynucleinIBA
01/2019 - 12/2015
2Glutathione (Reduced Glutathione)IBA
10/2018 - 11/2009
2CholesterolIBA
03/2016 - 11/2013
2Acetyl Coenzyme A (Acetyl-CoA)IBA
04/2013 - 02/2004
2GlycolipidsIBA
05/2011 - 01/2004
2phosphatidylglucoseIBA
05/2011 - 06/2010
2GlycosphingolipidsIBA
08/2006 - 02/2006
2alpha-N-Acetylgalactosaminidase (N-Acetyl-alpha-D-Galactosaminidase)IBA
01/2005 - 05/2002
1Complement C5 (Complement 5)IBA
01/2021
1GalactosidasesIBA
01/2021
1Retinaldehyde (Retinal)IBA
01/2021
1Biological ProductsIBA
06/2020
1SphingosineIBA
04/2020
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
04/2020
1EnzymesIBA
04/2020
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
07/2019
1DiglyceridesIBA
10/2018
1src-Family KinasesIBA
10/2018
1phosphatidylcholine-ceramide phosphocholine transferaseIBA
10/2018
1NADP (NADPH)IBA
10/2018
1NucleotidesIBA
10/2018
1Glycerophospholipids (Phosphoglycerides)IBA
09/2016
1Endopeptidase K (Proteinase K)IBA
12/2015
1beta-Galactoside alpha-2,3-SialyltransferaseIBA
12/2014
1SialyltransferasesIBA
12/2014
1LuciferasesIBA
10/2014
1Transcription Factors (Transcription Factor)IBA
10/2014
1Messenger RNA (mRNA)IBA
09/2014
1Cholinergic Agents (Cholinergics)IBA
05/2013
1Amyloid (Amyloid Fibrils)IBA
05/2013
1PresenilinsIBA
05/2013
1Presenilin-1IBA
07/2012
1Flavin-Adenine Dinucleotide (FAD)IBA
07/2012
1GlucosyltransferasesIBA
05/2011
1SterolsIBA
05/2011
1N-Methylaspartate (NMDA)IBA
12/2010
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
12/2010
1AldehydesIBA
11/2009
1Growth Hormone (Somatotropin)IBA
07/2009
1STAT5 Transcription FactorIBA
07/2009
1Pharmaceutical PreparationsIBA
07/2008
1Doxorubicin (Adriamycin)FDA LinkGeneric
07/2008
1Membrane LipidsIBA
10/2007
1Detergents (Detergent)IBA
10/2007
1Monoclonal AntibodiesIBA
10/2007

Therapy/Procedure

1Therapeutics
01/2019
1Lasers (Laser)
01/2013
1Drug Therapy (Chemotherapy)
07/2008